Until recently, calcium hydroxide paste was the main option used in temporary disinfection procedures in endodontic treatment; however, this material has some limitations. It is difficult to apply and remove from inside root canals and, as a major disadvantage, it is highly soluble in water (1.2 g.L-1) which causes rapid dissolution in the environment, resulting in limited clinical benefit.

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BIO-C^® TEMP is a bioceramic-based intracanal medication that has a significant advantage over calcium hydroxide pastes in that it has low solubility and thus can remain in contact with the canal walls for an extended period. As a result, hydroxyl ions (OH-) are continuously and gradually released.

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This continuous and gradual release of hydroxyl ions (OH-) allows BIO-C^® TEMP to make the environment unsuitable for microorganism growth by increasing the pH of the fluid surrounding the application. Raising the pH is important in preventing microorganism proliferation via the processes of protein denaturation and plasma membrane destabilization.